การพัฒนาเซรั่มผสมสารสกัดจากเปลือกผลไม้ที่มีฤทธิ์ยับยั้งเชื้อแบคทีเรียก่อโรคผิวหนัง
Serum Development of Fruit Peel Extracts Against Skin Pathogenic Bacteria
Abstract
ปัจจุบันผลิตภัณฑ์เซรั่มมีคุณสมบัติในการเพิ่มความชุ่มชื้นแก่ผิวหนัง อย่างไรก็ตามการพิจารณาประสิทธิภาพในการยับยั้งการเจริญเติบโตของจุลินทรีย์ที่ก่อให้เกิดโรคผิวหนังเป็นปัจจัยสำคัญที่ช่วยเพิ่มคุณค่าทางการใช้งานของผลิตภัณฑ์ดังกล่าว งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนาเซรั่มที่มีฤทธิ์ต้านแบคทีเรียก่อโรคผิวหนัง โดยใช้สารสกัดจากเปลือกผลไม้ไทย 5 ชนิด ได้แก่ ทับทิม ทุเรียน ส้มโอ มังคุด และกล้วย ในการศึกษาความสามารถในการยับยั้งแบคทีเรียสายพันธุ์ Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus และ Staphylococcus epidermidis โดยทำการสกัดสารออกฤทธิ์ 2 วิธี ได้แก่ การสกัดด้วยน้ำและการสกัดด้วยเอทานอล 95% ผลการทดลองพบว่าเซรั่มที่มีส่วนผสมของสารสกัดเปลือกทับทิม ร้อยละ 1 สามารถยับยั้งการเจริญเติบโตของแบคทีเรียได้อย่างมีประสิทธิภาพมากที่สุด การประเมินความชอบพบว่าเซรั่มที่ผสมสารสกัดจากเปลือกทับทิมได้รับความนิยมสูงสุดในกลุ่มผู้เข้าร่วมการทดสอบ ดังนั้นสารสกัดจากเปลือกทับทิมจึงมีศักยภาพในการนำไปพัฒนาเป็นสารออกฤทธิ์หลักในผลิตภัณฑ์เซรั่ม เพื่อสุขอนามัยผิวหนังและอาจเป็นทางเลือกที่มีความปลอดภัยและยั่งยืนสำหรับการควบคุมการติดเชื้อจากจุลินทรีย์บนผิวหนังในอนาคต
Currently, serum products are widely recognized for their moisturizing properties. However, consideration of their antimicrobial efficacy against skin pathogens is also important to enhance the functional value of these products. This study aimed to develop serum products with antibacterial activity against common skin pathogens. The extracts in this study were obtained from the peels of five Thai fruits: pomegranate, durian, pomelo, mangosteen, and banana. The bacterial strains tested included Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus, and Staphylococcus epidermidis. The antibacterial activity of each extract and serum was evaluated. Two extraction methods were used: aqueous extraction and 95% ethanol extraction. The results showed that the serum containing 1% pomegranate peel extract exhibited the strongest antibacterial activity. Furthermore, the preference test revealed that most participants favored the serum containing pomegranate peel extract. Therefore, pomegranate peel extract may serve as a potential antibacterial ingredient in skincare serum products, contributing to improved skin hygiene and providing a safe and sustainable option for controlling microbial infections on the skin in the future.
Keywords
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DOI: 10.14416/j.kmutnb.2025.11.001
ISSN: 2985-2145
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