Modeling Impacts of Dengue Vaccination on Sequential Epidemics

Abstract

The efficiency of dengue vaccines in preventing the infection from multi strain dengue virus is crucial for public health prevention strategies. To understand how the vaccine interrupts the transmission cycle between strains is an important task leading to the prevention plan. We use a mathematical model to investigate the impact of vaccine on the subsequent spread of two dengue virus serotypes. The model suggests how to maintain sufficient amount of vaccine coverage to prevent the subsequent epidemics and the effect of vaccine on the interaction between strains.