The Effectiveness of Dengue Vaccine and Vector Control: Model Study

Abstract

The first of commercial dengue vaccine called Dengvaxia, was approved in Mexico, Brazil and the several countries. The objective of this study is to estimate the effectiveness of the vaccine to number dengue infection by using mathematical model of dengue transmission with multiple serotypes of dengue virus. The vaccine is given to a certain part of population in the community and the number of dengue infections and incidences is then calculated. The combination of vector control methods and vaccination is also evaluated. The results shown that the cooperation between both programs is reduced the number of dengue infection by more than 90% with 50% of vaccine coverage. The vaccination or vector control programs alone are unable to eliminate dengue infection from community.